Increasing anastomosis safety and preventing abdominal adhesion formation by the use of polypeptides in the rat

Int J Colorectal Dis. 2005 Nov 3;:1-7 [Epub ahead of print]
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Increasing anastomosis safety and preventing abdominal adhesion formation by the use of polypeptides in the rat.Tingstedt B, Nehez L, Axelsson J, Lindman B, Andersson R.Department of Surgery, Centre of Chemistry and Clinical Engineering, Lund University, Lund, Sweden.BACKGROUND AND AIMS: Postoperative adhesions can potentially be reduced using different anti-adhesive agents, though these drugs tend to compromise healing of an intestinal anastomosis. No method that significantly increases anastomosis safety is known at present. The aim of the study was to develop a concept of preventing postoperative adhesions using differently charged bioactive polypeptides, also considering healing and safety of an intestinal anastomosis. METHODS: An ileocolic anastomosis was performed under both "clean" and "septic" conditions in the rat. The treatment group received intraperitoneal poly-L: -lysine and poly-L: -glutamate, while controls received sodium chloride. Abdominal adhesions, anastomosis leakage and burst pressure were analysed after 1, 3, 5 and 7 days in the clean anastomosis model and after 7 days in the septic model. RESULTS: A significant decrease (p<0.01)>